Fig. 3
The metabolic profiles in the urine. The HFD induced hyperlipidemic rats were treated with or without BC for 4-week, urine was collected, and metabolomics analysis was made by GC/MS. a PCA score plots of urine samples from BC treated group and untreated group; b scores plots of OPLS-DA between untreated group and BC treated group; c Pearson’s correlations of the quantities of the 35 metabolites determined from rat urine samples; d heat map showing the FC of 19 metabolites. Shades of blue represent FC decrease while red represent FC increase; e simplified draft illustrating perturbed pathways involved; f differential metabolites between groups in vitamin B6 metabolism; g differential metabolites between groups in phenylalanine metabolism. Values were showed as mean peak intensities ± SEM. *P < 0.05, **P < 0.01 and ***P < 0.001, compared with untreated (HFD) group