Fig. 1

GLP-1R expression in different species and tissues: a Murine endocrine islet cells (αTC1 and βTC3), rat L6 myoblast (Bl) and myotube (Tb), human skeletal muscle (M) and baboon adipose (A) muscle (M) liver (L) and brain (B). Time course of EXE-induced 2DG uptake in L6 myotubes b Myotubes were stimulated with 100 nmol/l for 20 min, and 2, 4, 24, and 48 h and with 100 nmol/l insulin (INS) for 30 min as control. Effects of co-incubation with EXE and insulin on 2DG-glucose uptake c Myotubes were stimulated with either 100 nmol/l EXE, 100 nmo/l INS and both. Data are shown as mean ± SD of three independent experiments. (*p < 0.001, **p < 0.01 vs control)