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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: A short CD3/CD28 costimulation combined with IL-21 enhance the generation of human memory stem T cells for adoptive immunotherapy

Fig. 3

IL-21 enhances CD4+ and CD8+ TSCM frequencies. Naïve T cells from healthy donors (n = 6) were cultured for 10 days with short (solid black line) or long (solid grey line) costimulation and in the presence (black dashed line) or absence (grey dashed line) of IL-21. a, b Frequencies of CD4+ and CD8+ TSCM (mean ± SEM) are shown in (a) and (b), respectively. c, d Frequencies of CD4+ and CD8+ Total TSCM (TSCM + TSCM-like) (mean ± SEM) are shown in (c) and (d), respectively. *p < 0.05; **p < 0.01; ***p < 0.001

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