Fig. 5

Concentration-response curves to acetylcholine before and after incubation with diethyldithiocarbamate (DETCA, A and B), or apocynin (Apo, D and E) in thoracic aortic rings from sedentary (S) and exercise-trained (Ex) wild-type (WT) and LDLr knockout mice (LDLr^−/−). Bar graphs show the acetylcholine maximal vasodilator effect (E_max) in the presence or absence of DETCA (C) and Apo (F). ANOVA: * p < 0.05 vs. WT S;^# p < 0.05 vs. LDLr^−/− S; + indicates p < 0.05, ++ indicates p < 0.001, and +++ indicates p < 0.0001 vs. without incubation rings. Data are mean ± SEM (n = 5–8 per group)