Fig. 2

Concentration-response curves to acetylcholine before and after incubation with L-NAME (LN, A and B), 7-Nitroindazole (7-NI, D and E) or catalase (CAT, G and H) in thoracic aortic rings from sedentary (S) and exercise-trained (Ex) wild-type (WT) and LDLr knockout mice (LDLr^−/−). Bar graphs show the acetylcholine maximal vasodilator effect (E_max) in the presence or absence of L-NAME (C), 7-NI (F) and CAT (I). ANOVA: * p < 0.05 vs. WT S;^# p < 0.05 vs. LDLr^−/− S; + indicates p < 0.05, ++ indicates p < 0.001, and +++ indicates p < 0.0001 vs. without incubation ring. Data are mean ± SEM (n = 5–8 per group)