Fig. 2

MACC1 cytoplasmic percentage (C %) staining to diagnose between adenoma vs. normal and cancer vs. normal tissues. Both adenoma and CRC samples had significantly higher staining percentages compared with normal tissue. Adenoma vs CRC cases had similar MACC1 staining (ROC (95 % CI) 0.47 (0.40–0.55, not shown). a Staining % had a area under ROC curve of 70 % (95 % CI 59–80 %) to diagnose between adenoma and normal samples with highest diagnostic ability in 100 % staining (with Sensitivity = 0.84 and Specificity = 0.60). b Staining % had a area under ROC curve of 67 % (95 % CI 59–80 %) to diagnose between CRC and normal samples with highest diagnostic ability in 100 % staining (with Sensitivity = 0.78 and Specificity = 0.60)