Fig. 1

a FAMOUS SVS pulse sequence diagram with three acquisition blocks. b RF diagram for water reference acquisitions with all the saturation pulses off and gradients on along with optional OVS pulses. c, d RF diagram for water-suppressed control and inversion acquisition showing the seven water saturation pulses (α1–α7) along with the delays (d1–d7), two FSI pulse and optional OVS pulses. For the water-suppressed metabolite nulled control and inversion acquisition there are two additional inversion pulses (IR), one set at the beginning of the acquisition while the second one is set in between the third and fourth water saturation pulse e Gradients along x, y and z axes are all same for the three acquisitions