Fig. 1

Functional genomic analysis of 5hmC. a Left: Violin plot showing the distribution of CpG density for the frequently hydroxymethylated sites (FhmC) and the background sites in the Infinium HumanMethylation450 microarray (Wilcoxon non-parametric test; p < 0.001, D = −0.47). Center: Stacked bar chart showing the relative proportions of CpG sites classified according to their CpG Island status in the frequently hydroxymethylated and background sites (Chi square test; p < 0.001, OR 3.62). Right: Stacked bar chart describing the classification of FhmC and background sites according to their relative genomic location (Chi square test; p < 0.001, OR 1.63). b Violin plots showing the distances to centromeres (left) and telomeres (right) of the FhmC sites and background probes (Wilcoxon non-parametric test; p < .01; D = 0.02 and p < .001; D = 0.06, respectively)