Fig. 5

The fate of 110 tdT⁺ clones was diverse despite a balanced population size. 110 tdT⁺ clones were identified 20 days after labeling (a), Histograms b–d show individual tdT⁺ clone fates at the indicated times post-labeling and the evolution of this process over 323 days. For example, at 323 post labeling, 45 clones were undetectable, 25 remained 1 cell, and 40 expanded to 2–5 cells. Analysis of the population showed that the survival or clone density decreased and stabilized over 323 days (e). Quantitative analysis showed that the average tdT⁺ clone size (calculated by dividing the number of total starting tdT⁺ clones (110)/the number of tdT⁺ cells at a given point in time) remained approximately one over 323 days (f). This was pooled data from 4 Lyve1CreERT2^tdT mice