Fig. 2

a Combined irbesartan/losartan drug mechanism of action molecular model holding 48 protein coding genes (nodes) organized in seven molecular process segments (boxes). Protein interactions are indicated as edges, interactions of proteins across process segments are omitted. b Interference of ARB mechanism of action model on the DKD molecular model. Matching network segments are shown as red nodes. Nodes colored in blue identify enzymes associated with metabolites included in the classifier, nodes in pink indicate metabolite transport. c Gene symbols for selected nodes matching in drug and DKD molecular models, and associated metabolites in case of enzymes according to Table 4