Classical V600E and other non-hotspot BRAF mutations in adult differentiated thyroid cancer

Table 4 Comparison of clinical and histopathological characteristics between patients with positive and negative BRAF ^V600E mutation in adult DTCs

Characteristics	BRAF ^V600E mutation	BRAF wild type	P value
Characteristics	(95 cases)	(105 cases)	P value
Age mean ± SD (years)	43.5 ± 15	36.2 ± 13.3	0.0001*
Sex (female:male)	71:24	79:26	1.00
Tumor size	3.05 ± 1.97	3.31 ± 2.43	0.42
Tumor multifocality	49 (51.6 %)	48 (45.7 %)	0.49
Extrathyroidal invasion	54 (56.8 %)	41 (39 %)	0.017*
Lymph node metastasis	51 (53.7 %)	40 (38.1 %)	0.038*
Distant metastasis	6 (6.3 %)	9 (8.6 %)	0.74
TNM stage III/IV	31 (32.6 %)	13 (12.4 %)	0.001*
Persistent disease (6–12 months after initial management)	47 (49.5 %)	43 (40.96 %)	0.29
Persistent/recurrent disease (At last follow up)	37 (38.9 %)	30 (28.6 %)	0.16

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