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Table 4 Comparison of clinical and histopathological characteristics between patients with positive and negative BRAF V600E mutation in adult DTCs

From: Classical V600E and other non-hotspot BRAF mutations in adult differentiated thyroid cancer

Characteristics BRAF V600E mutation BRAF wild type P value
(95 cases) (105 cases)
Age mean ± SD (years) 43.5 ± 15 36.2 ± 13.3 0.0001*
Sex (female:male) 71:24 79:26 1.00
Tumor size 3.05 ± 1.97 3.31 ± 2.43 0.42
Tumor multifocality 49 (51.6 %) 48 (45.7 %) 0.49
Extrathyroidal invasion 54 (56.8 %) 41 (39 %) 0.017*
Lymph node metastasis 51 (53.7 %) 40 (38.1 %) 0.038*
Distant metastasis 6 (6.3 %) 9 (8.6 %) 0.74
TNM stage III/IV 31 (32.6 %) 13 (12.4 %) 0.001*
Persistent disease (6–12 months after initial management) 47 (49.5 %) 43 (40.96 %) 0.29
Persistent/recurrent disease (At last follow up) 37 (38.9 %) 30 (28.6 %) 0.16
  1. * Statistically significant