Fig. 5

Regulation of PEG10 expression by miR-122 in different model systems. In cell cultures, binding of miR-122 to sites 2310 and 2403 in the 3′-UTR of the PEG10 transcript suppressed PEG10 protein expression. In mice, PEG10 protein level was increased by miR-122 deficiency. In HCC patient tissue, there was no strong relationship between miR-122 and PEG10 levels in normal and tumor tissue, suggesting that other factors regulate PEG10 expression in HCC patients