Fig. 5

Local tissue innervation in OA and AL patients. a–d NF200+ fibers (red) as sole fiber or organized in neurome-like structures in OA synovial tissues as well as in aseptic interface membranes. e Synovial cells expressing TH (red). f TH+ fiber surround a blood vessel. g, h Nor fibrotic nor reactive tisue with giant cells presented positive labelling for TH. i SP+ cells in OA synovium membrane. j SP+ fibers and SP+ cells surrounding a blood vessel located at subintimia of OA synovial tissue. k, l In AL patients, SP+ fibers were just found in fibrotic regions. m CGRP+ cells in synovial membrane. n CGRP+ fibers along a blood vessel in OA synovial tissue. o, p Some cells expressing CGRP in aspetic interface tissue. red = NF200+ or TH+ or SP+ or CGRP+ , blue = cell nuclei, green = autofluorescence) Scale bars correspond to 50 μm (a, b, d, f, g, h, i, j, k, l, m, n, o, p), 200 μm (e) and 100 μm (c)