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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Rebamipide prevents peripheral arthritis and intestinal inflammation by reciprocally regulating Th17/Treg cell imbalance in mice with curdlan-induced spondyloarthritis

Fig. 4

Rebamipide reciprocally regulates Th17/Treg cell imbalance. Spleen tissues were isolated from mice in each group at 14 weeks after curdlan injection. a The tissues were stained with specific Abs against CD4 (green), CD25 (white), IL-17 (red), FOXP3 (green), p-STAT3–Y705 (red), and p-STAT3–S727 (red). Positive cells are shown in the bar graphs. b Spleen tissues were isolated from mice in each group at 14 weeks after curdlan injection. Splenocytes were stained with Abs against CD4–PerCP, IL-17–PE, and IL-10–FITC to determine the presence of Th17 and IL-10-expressing Treg cells. Data are expressed as the mean ± SEM of 3 independent experiments (*P < 0.05)

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