Fig. 4

Gene expression levels of the Tgfb1/TGFB1 cascade in human OP lesions, compared to controls. TGFB1/Tgfb1, CXCL12/Cxcl12, TIMP1/Timp1, TIMP2/Timp2, COL3A1/Col3a1 and MMP2/Mmp2 show an OP lesion-specific overexpression in both human and murine lungs. In contrast, BMP4 and BMPR1B were upregulated in human OP lesions, compared to controls, while in murine lungs both genes were downregulated. There was no significant difference in the expression level of IL6/Il6. Ctrl.—control(s)