Fig. 2

OP lesions stained by hematoxylin and eosin (a, d), and immunohistochemically against MMP2 (b, e) and IL6 (c, f) in transgenic mice (a–c) and in human OP lungs (d–f). Histopathologically, the organizing pneumonia pattern (arrows), which is characterized by excessive intraalveolar proliferations of granulation tissue, associated with lymphocytic pneumonitis in the surrounding lung tissue, is comparable in humans and mice. Scale bars correspond to 100 µm