Exosomes in the nose induce immune cell trafficking and harbour an altered protein cargo in chronic airway inflammation

Table 2 Proteins with altered expression in airway disease

Acc.	Protein	Asthma + CRS vs control		Asthma only vs control		Asthma + CRS vs Asthma only
Acc.	Protein	A	B	A	B	A	B
A^a
Q8TAX7	MUC7	+4.0	+1.4	+2.9	+1.8
P68871	HBB	+2.2	+1.3	+2.0	+2.7
P00738	HP	+1.8	+1.3	+1.7	+1.8
P02788	LTF	−1.5	−1.3	−1.9	−1.6
Q9GZZ8	LACRT	−1.3	−2.0	−1.5	−2.8
B^b
P02768	ALB	+1.3	+1.4
P01857	IGHG1	+1.3	+1.6
P05109	S100A8	−1.5	−1.5
P06702	S100A9	−1.5	−1.4
P80511	S100A12	−1.4	−2.3
C^c
Q9HC84	MUC5B			+2.2	+2.4
P20930	FLG			−1.4	−2.9
P01591	IGJ			−1.3	−1.5
P01876	IGHA1			−1.4	−1.3
P01833	PIGR			−1.3	−1.4
Q86YZ3	HRNR			−1.8	−3.8
D^d
Q08380	LGALS3BP					+1.6	+1.5
Q86YZ3	HRNR					+3.6	+1.3
P05109	S100A8					−1.3	−2.1
P06702	S100A9					−1.3	−1.9
P80511	S100A12					−1.6	−1.8
P60709	ACTB					−1.2	−1.5
P35579	MYH9					−1.6	−1.6
P08311	CTSG					−2.9	−1.5

Only proteins with greater than 1.3-fold change in both pool A and pool B are presented. A negative value (“−”) means negative fold change of the first disease compared to second state, while a positive value (“+”) means positive fold change
Acc GenBank accession number; ACTB actin, cytoplasmic 1; ALB serum albumin; CTSG cathepsin G; FLG filaggrin; HBB hemoglobin subunit B; HP haptoglobin; HRNR hornerin; IGHA1 Ig alpha-1 chain C region; IGHG1 Ig gamma-1 chain C region; IGJ Immunoglobulin J chain; LACRT extracellular glycoprotein lacritin; LGALS3BP Galectin-3-binding protein; LTF lactotransferrin; MUC5B mucin-5B; MUC7 mucin-7; MYH9 myosin-9; PIGR polymeric immunoglobulin receptor
^aProteins altered in both asthma + CRS and asthma only against the control
^bProteins altered in asthma + CRS compared to control
^cProteins altered in asthma only compared to control
^dProteins altered in asthma + CRS compared to asthma only

ISSN: 1479-5876