Fig. 3

PGC-1α, ERR-1α, SREBP-1, pACC and intrarenal lipid levels in the renal cortex of the db/m and db/db mice with or without resveratrol. Protein lysates (40 μg) from renal cortexes were separated by SDS–PAGE and analyzed by western blot. a Representative results are for PGC-1α, ERR-1α, SREBP-1, pACC and β-actin and quantitative analyses of areas are for PGC-1α/β-actin, ERR-1α/β-actin, SREBP-1/β-actin, and pACC. *p < 0.05 and **p < 0.01 vs. db/m, db/m Res and db/db Res mice, respectively. b Quantitative analyses are for intrarenal NEFA, TG and total cholesterol concentrations. **p < 0.01 and ^#p < 0.001 vs. db/m, db/m Res and db/db Res mice, respectively. c Oil red O staining from db/m and db/db mice with or without resverastrol (original magnification ×400). PGC-1α PPARγ co-activator 1α, ERR-1α estrogen-related receptor-1α, pACC phosphorylated acetyl-CoA carboxylase, SREBP 1c sterol regulatory element-binding protein 1c, Res resveratrol, NEFA nonesterified fatty acid, TG triacylglycerol