Fig. 4

Differentiated PDAC tumor models have less collagen and grow faster than non-differentiated PDAC tumor models. Level of differentiation (a), amount of collagen I (b), amount of collagen IV (c), and volume doubling time (d) of BxPC-3, Capan-2, MIAPaCa-2, and Panc-1 tumors. The individual tumors of the same model were indistinguishable histologically in both HE stained and immunostained sections, but differed in growth rate. Columns and bars in (d) Mean ± SEM of 12–16 tumors