Fig. 2
MR images of a representative tumor. T 2-weighted anatomical image (a) and T 1-weighted images (b–h) from an experiment with a BxPC-3 tumor. The T 1-weighted images were recorded with a fast spin echo pulse sequence for calculation of precontrast T 1 values (b) or with a three-dimensional SPGR sequence for acquiring dynamic series (c–h). Dynamic images were recorded before and every 14.8 s after contrast administration. The dynamic images in (c–h) refer to a precontrast image (c, d) and images recorded 1 min (e), 5 min (f), 10 min (g), and 15 min (h) after contrast administration. The region within the square in (c) is highlighted in (d–h). Tumor regions of interest (ROI) were depicted in the anatomical image (a) and were transferred to the other images since the different pulse sequences were performed with identical geometrical settings. The tumor ROI is outlined with black in the images (a–h). The coordinates of the tumor voxels are defined by the white grids (one line per 20 voxels) in (d–h). The images illustrate that the tumor did not move or change shape during the MRI. Scale bars 5 mm