Development and validation of a classification and scoring system for the diagnosis of oral squamous cell carcinomas through confocal laser endomicroscopy

Table 5 Classification performance of the chosen parameters for the score sheet (by experts)

Parameters (score sheet)	Occurrence frequency, %; anomalies in		Chi square test (n = 95)	Correlations (n = 95)
Parameters (score sheet)	Physiological mucosa (n = 45)	OSCC (n = 50)	P value	P value (2 tailed)	Spearman’s rho
Homogeneity	15.6 (7/45)	100 (50/50)	<0.001	<0.001	0.936
Intercellular gaps	37.8 (17/45)	100 (50/50)	<0.001	<0.001	0.880
Cell morphology	28.9 (13/45)	100 (50/50)	<0.001	<0.001	0.949
Fluorescein leakage	22.2 (10/45)	78 (39/50)	<0.001	<0.001	0.557
Vessel morphology	17.8 (8/45)	92 (46/50)	<0.001	<0.001	0.748

Occurrence frequency of anomalies (mildly or highly dysplastic) in physiological mucosa and OSCCs, Chi square test and Spearman’s correlation

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