Fig. 1
From: mTOR inhibitors effects on regulatory T cells and on dendritic cells
Adapted from Mark B. Feinberg & Guido Silvestri: TS cells and immune tolerance induction: a regulatory renaissance? Nature Immunology 2002; 3: 215–217
A potential mTOR inhibithor-modulated immune mechanism. The figure summarized the possible tolerogenic effect induced by mTOR inhibition through a specific sequence of events characterized by an increase in circulating C8+C28− Ts followed by a significant increase of ILT3 and ILT4 expression on circulating DCs due to a strong reduction of CD40 expression