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Table 4 Expression of serine/glycine metabolism-related proteins according to the histologic subtype of follicular carcinoma

From: Expression of serine/glycine metabolism-related proteins is different according to the thyroid cancer subtype

Parameters

Total n = 112 (%)

FC, minimally invasive type n = 99 (%)

FC, widely invasive type n = 13 (%)

p value

PHGDH in tumor

0.454

 Negative

58 (51.8)

50 (50.5)

8 (61.5)

 

 Positive

54 (48.2)

49 (49.5)

5 (38.5)

 

PSAT1 in tumor

1.000

 Negative

103 (92.0)

91 (91.9)

12 (92.3)

 

 Positive

9 (8.0)

8 (8.1)

1 (7.7)

 

PSPH in tumor

0.357

 Negative

101 (90.2)

88 (88.9)

13 (100.0)

 

 Positive

11 (9.8)

11 (11.1)

0 (0.0)

 

SHMT1 in tumor

0.689

 Negative

94 (83.9)

82 (82.8)

12 (92.3)

 

 Positive

18 (16.1)

17 (17.2)

1 (7.7)

 

GLDC in tumor

1.000

 Negative

96 (85.7)

85 (85.9)

11 (84.6)

 

 Positive

16 (14.3)

14 (14.1)

2 (15.4)

 
  1. PHGDH phosphoglycerate dehydrogenase; PSAT phosphoserine aminotransferase; PSPH phosphoserine phosphatase; SHMT serine hydromethyl transferase; GLDC glycine decarboxylase