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Table 3 Expression of serine/glycine metabolism-related proteins in follicular neoplasm

From: Expression of serine/glycine metabolism-related proteins is different according to the thyroid cancer subtype

Parameters Total n = 264 (%) Follicular adenoma n = 152 (%) Follicular carcinoma n = 112 (%) p value
PHGDH in tumor 0.274
 Negative 147 (55.7) 89 (58.6) 58 (51.8)  
 Positive 117 (44.3) 63 (41.4) 54 (48.2)  
PSAT1 in tumor 0.001
 Negative 219 (82.6) 116 (75.8) 103 (92.0)  
 Positive 46 (17.4) 37 (24.2) 9 (8.0)  
PSPH in tumor 0.328
 Negative 244 (92.1) 143 (93.5) 101 (90.2)  
 Positive 21 (7.9) 10 (6.5) 11 (9.8)  
SHMT1 in tumor 0.137
 Negative 211 (79.6) 117 (76.5) 94 (83.9)  
 Positive 54 (20.4) 36 (23.5) 18 (16.1)  
GLDC in tumor 0.262
 Negative 234 (88.3) 138 (90.2) 96 (85.7)  
 Positive 31 (11.7) 15 (9.8) 16 (14.3)  
  1. PHGDH phosphoglycerate dehydrogenase; PSAT phosphoserine aminotransferase; PSPH phosphoserine phosphatase; SHMT serine hydromethyl transferase; GLDC glycine decarboxylase
  2. Italic value represents p < 0.05