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Table 3 Expression of serine/glycine metabolism-related proteins in follicular neoplasm

From: Expression of serine/glycine metabolism-related proteins is different according to the thyroid cancer subtype

Parameters

Total n = 264 (%)

Follicular adenoma n = 152 (%)

Follicular carcinoma n = 112 (%)

p value

PHGDH in tumor

0.274

 Negative

147 (55.7)

89 (58.6)

58 (51.8)

 

 Positive

117 (44.3)

63 (41.4)

54 (48.2)

 

PSAT1 in tumor

0.001

 Negative

219 (82.6)

116 (75.8)

103 (92.0)

 

 Positive

46 (17.4)

37 (24.2)

9 (8.0)

 

PSPH in tumor

0.328

 Negative

244 (92.1)

143 (93.5)

101 (90.2)

 

 Positive

21 (7.9)

10 (6.5)

11 (9.8)

 

SHMT1 in tumor

0.137

 Negative

211 (79.6)

117 (76.5)

94 (83.9)

 

 Positive

54 (20.4)

36 (23.5)

18 (16.1)

 

GLDC in tumor

0.262

 Negative

234 (88.3)

138 (90.2)

96 (85.7)

 

 Positive

31 (11.7)

15 (9.8)

16 (14.3)

 
  1. PHGDH phosphoglycerate dehydrogenase; PSAT phosphoserine aminotransferase; PSPH phosphoserine phosphatase; SHMT serine hydromethyl transferase; GLDC glycine decarboxylase
  2. Italic value represents p < 0.05