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Table 1 Expression of serine/glycine metabolism-related proteins according to the subtype of thyroid cancer

From: Expression of serine/glycine metabolism-related proteins is different according to the thyroid cancer subtype

Parameters Total n = 557 (%) PTC n = 344 (%) FC n = 112 (%) MC n = 70 (%) PDC n = 23 (%) AC n = 8 (%) P value
PHGDH in tumor <0.001
 Negative 252 (45.2) 126 (36.6) 58 (51.8) 59 (84.3) 5 (21.7) 4 (50.0)  
 Positive 305 (54.8) 218 (63.4) 54 (48.2) 11 (15.7) 18 (78.3) 4 (50.0)  
PSAT1 in tumor 0.001
 Negative 477 (85.6) 280 (81.4) 103 (92.0) 69 (98.6) 18 (78.3) 7 (87.5)  
 Positive 80 (14.4) 64 (18.6) 9 (8.0) 1 (1.4) 5 (21.7) 1 (12.5)  
PSPH in tumor 0.008
 Negative 497 (89.2) 300 (87.2) 101 (90.2) 70 (100.0) 18 (78.3) 8 (100.0)  
 Positive 60 (10.8) 44 (12.8) 11 (9.8) 0 (0.0) 5 (21.7) 0 (0.0)  
SHMT1 in tumor <0.001
 Negative 415 (74.5) 236 (68.6) 94 (83.9) 63 (90.0) 16 (69.6) 6 (75.0)  
 Positive 142 (25.5) 108 (31.4) 18 (16.1) 7 (10.0) 7 (30.4) 2 (25.0)  
SHMT1 in stroma <0.001
 Negative 413 (74.1) 212 (61.6) 112 (100.0) 65 (92.9) 21 (91.3) 3 (37.5)  
 Positive 144 (25.9) 132 (38.4) 0 (0.0) 5 (7.1) 2 (8.7) 5 (62.5)  
GLDC in tumor 0.529
 Negative 470 (84.4) 285 (82.8) 96 (85.7) 60 (85.7) 21 (91.3) 8 (100.0)  
 Positive 87 (15.6) 59 (17.2) 16 (14.3) 10 (14.3) 2 (8.7) 0 (0.0)  
  1. PTC papillary thyroid carcinoma; FC follicular carcinoma; MC medullary carcinoma; PDC poorly differentiated carcinoma; AC anaplastic carcinoma; PHGDH phosphoglycerate dehydrogenase; PSAT phosphoserine aminotransferase; PSPH phosphoserine phosphatase; SHMT serine hydromethyl transferase; GLDC glycine decarboxylase
  2. Italic values represent p < 0.05