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Table 2 Maximal relaxation (E max) and half-maximal dose (logEC50) in response to carbachol and glyceryl trinitrate in 16 weeks old rats

From: Modulation of the sympathetic nervous system by renal denervation prevents reduction of aortic distensibility in atherosclerosis prone ApoE-deficient rats

  SD-sham SD-RDN ApoE−/−-sham ApoE−/−-RDN
Number of rats 5 5 5 5
Response to carbachol
 E max, (%) 67 ± 6.0 73 ± 3.3 43 ± 4.8§ 53 ± 4.9
 logEC50 (log M) −6.22 ± 0.06 −6.17 ± 0.03 −5.81 ± 0.15 −5.88 ± 0.12
Response to glyceryl trinitrate
 E max, (%) 232 ± 24 237 ± 6 209 ± 13 217 ± 16
 logEC50 (log M) −6.5 ± 0.10 −6.47 ± 0.08 −6.32 ± 0.06 −6.29 ± 0.10
  1. Values are mean ± SEM. p values were calculated using one-way-Anova followed by Tukey´s multiple comparisons test
  2. §p = 0.01 SD-sham vs. ApoE−\−-sham