Modulation of the sympathetic nervous system by renal denervation prevents reduction of aortic distensibility in atherosclerosis prone ApoE-deficient rats

Table 2 Maximal relaxation (E _max) and half-maximal dose (logEC₅₀) in response to carbachol and glyceryl trinitrate in 16 weeks old rats

	SD-sham	SD-RDN	ApoE^−/−-sham	ApoE^−/−-RDN
Number of rats	5	5	5	5
Response to carbachol
E _max, (%)	67 ± 6.0	73 ± 3.3	43 ± 4.8^§	53 ± 4.9
logEC₅₀ (log M)	−6.22 ± 0.06	−6.17 ± 0.03	−5.81 ± 0.15	−5.88 ± 0.12
Response to glyceryl trinitrate
E _max, (%)	232 ± 24	237 ± 6	209 ± 13	217 ± 16
logEC₅₀ (log M)	−6.5 ± 0.10	−6.47 ± 0.08	−6.32 ± 0.06	−6.29 ± 0.10

Values are mean ± SEM. p values were calculated using one-way-Anova followed by Tukey´s multiple comparisons test
^§p = 0.01 SD-sham vs. ApoE^−\−-sham

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