| |
SD-sham n = 5
|
SD-RDN n = 6
|
ApoE−/−-sham n = 5
|
ApoE−/−-RDN n = 6
|
|---|
|
Body weight (g)
|
456.2 ± 25.64
|
474.14 ± 11.26
|
446.75 ± 3.68
|
456.2 ± 10
|
|
Heart weigth (g)
|
1.41 ± 0.04
|
1.45 ± 0.05
|
1.51 ± 0.06
|
1.45 ± 0.04
|
|
Heart rate (bpm)
|
360 ± 9
|
370 ± 10
|
341 ± 13
|
359 ± 7
|
|
Blood pressure (mmHg)
|
|
Systolic
|
144 ± 5
|
137 ± 4
|
148 ± 12
|
136 ± 7
|
|
Diastolic
|
116 ± 4
|
109 ± 10
|
121 ± 11
|
99 ± 8
|
|
Stroke volume (µl)
|
210 ± 10
|
219 ± 5
|
203 ± 10
|
224 ± 9
|
|
Ejection fraction (%)
|
61 ± 3
|
61 ± 1
|
59 ± 2
|
60 ± 2
|
|
LVEDV (µl)
|
342 ± 11
|
357 ± 11
|
344 ± 8
|
372 ± 13
|
|
LVESV (µl)
|
131 ± 12
|
137 ± 8
|
140 ± 11
|
148 ± 10
|
|
Serum chemistry
|
|
GPT (U/l)
|
79.64 ± 7.53
|
70.5 ± 5.91*
|
109.66 ± 14.96
|
104.43 ± 10.26
|
|
GOT (U/l)
|
178.36 ± 24.74
|
169.64 ± 13.83
|
222.22 ± 33.31
|
217.28 ± 32.1
|
|
Creatinine (mg/dl)
|
0.306 ± 0.02
|
0.33 ± 0.01
|
0.33 ± 0.02
|
0.29 ± 0.03
|
|
Glucose (mg/dl)
|
235.2 ± 8.24
|
268.71 ± 17.18
|
328.25 ± 28.51
|
289.33 ± 25.65
|
|
Cholesterol (mg/dl)
|
48.2 ± 3.28§
|
45.71 ± 3.21#
|
131.5 ± 17.54
|
152.5 ± 13.63
|
|
Triglycerides (mg/dl)
|
30.6 ± 7.04§
|
30.57 ± 8.05#
|
152.2 ± 27.41
|
152.5 ± 18.44
|
|
LDL (mg/dl)
|
10.96 ± 1.15§
|
10.5 ± 0.94#
|
52.3 ± 6.62
|
65.28 ± 9.61
|
|
HDL (mg/dl)
|
37.58 ± 1.36§
|
34.93 ± 3.36#
|
11.7 ± 1.67
|
15.78 ± 1.81
|
- Values are mean ± SEM
-
LVEDV left ventricular end-diastolic volume, LVESV left ventricular end-systolic volume, GPT glutamat-pyruvat-transaminase, GOT glutamat-oxalacetat-transaminase, HDL high-density lipoprotein, LDL low-density lipoprotein
- * p < 0.05 SD-RDN vs. ApoE−\−-RDN
-
§p < 0.01 SD-sham vs. ApoE−\−-sham
-
#p < 0.01 SD-RDN vs. ApoE−\−-RDN (one-way-Anova followed by Tukey´s multiple comparisons test)
