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Table 2 Gene ontology analysis of hypomethylated GpG sites from birth to 5 years of age (with RR >2 and Q value <0.01)

From: Longitudinal study of DNA methylation during the first 5 years of life

Onthology

Term

RR

Q_value

Biological_process

Stress fiber assembly

23.288

0.00494

Biological_process

Positive regulation of T cell mediated immunity

4.9028

0.0066

Biological_process

Regulation of T cell mediated immunity

4.7907

0.00156

Biological_process

Positive regulation of cell killing

4.4359

0.00494

Biological_process

Response to type I interferon

3.502

0.00586

Biological_process

Interferon-gamma-mediated signaling pathway

3.3269

0.00653

Biological_process

Maintenance of protein location in cell

3.0629

0.00181

Biological_process

Cellular response to interferon-gamma

2.9322

0.00494

Biological_process

Maintenance of location in cell

2.9052

0.00191

Biological_process

Response to interferon-gamma

2.6615

0.00496

Biological_process

Actin cytoskeleton organization

2.0415

9.66E−05

Biological_process

Actin filament-based process

2.0231

3.32E−05

Molecular_function

Antigen binding

3.8842

0.00174

Molecular_function

Rho guanyl-nucleotide exchange factor activity

3.3577

0.00237

Molecular_function

Ras guanyl-nucleotide exchange factor activity

3.0522

0.00023

Molecular_function

Guanyl-nucleotide exchange factor activity

2.2431

0.00345

Cellular_component

MHC class I protein complex

11.685

0.00637

Cellular_component

MHC protein complex

7.2337

0.0005

Cellular_component

Integral component of lumenal side of endoplasmic reticulum membrane

4.8966

0.00844

Cellular_component

Lumenal side of membrane

4.8966

0.00844

Cellular_component

Lumenal side of endoplasmic reticulum membrane

4.8966

0.00844

Cellular_component

Main axon

3.9646

0.00124

Cellular_component

Cortical cytoskeleton

3.0207

0.00807

Cellular_component

Axon part

2.4846

0.00206

Cellular_component

Ruffle

2.1639

0.00663

  1. RR relative risk is a measure of effect size describing the change of proportions between our selected set of genes and a given term
  2. Q value Q value is the result from the adjustment of P values in order to control the false discovery rate (FDR) using the Benjamini-Hochberg method