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Table 2 Gene ontology analysis of hypomethylated GpG sites from birth to 5 years of age (with RR >2 and Q value <0.01)

From: Longitudinal study of DNA methylation during the first 5 years of life

Onthology Term RR Q_value
Biological_process Stress fiber assembly 23.288 0.00494
Biological_process Positive regulation of T cell mediated immunity 4.9028 0.0066
Biological_process Regulation of T cell mediated immunity 4.7907 0.00156
Biological_process Positive regulation of cell killing 4.4359 0.00494
Biological_process Response to type I interferon 3.502 0.00586
Biological_process Interferon-gamma-mediated signaling pathway 3.3269 0.00653
Biological_process Maintenance of protein location in cell 3.0629 0.00181
Biological_process Cellular response to interferon-gamma 2.9322 0.00494
Biological_process Maintenance of location in cell 2.9052 0.00191
Biological_process Response to interferon-gamma 2.6615 0.00496
Biological_process Actin cytoskeleton organization 2.0415 9.66E−05
Biological_process Actin filament-based process 2.0231 3.32E−05
Molecular_function Antigen binding 3.8842 0.00174
Molecular_function Rho guanyl-nucleotide exchange factor activity 3.3577 0.00237
Molecular_function Ras guanyl-nucleotide exchange factor activity 3.0522 0.00023
Molecular_function Guanyl-nucleotide exchange factor activity 2.2431 0.00345
Cellular_component MHC class I protein complex 11.685 0.00637
Cellular_component MHC protein complex 7.2337 0.0005
Cellular_component Integral component of lumenal side of endoplasmic reticulum membrane 4.8966 0.00844
Cellular_component Lumenal side of membrane 4.8966 0.00844
Cellular_component Lumenal side of endoplasmic reticulum membrane 4.8966 0.00844
Cellular_component Main axon 3.9646 0.00124
Cellular_component Cortical cytoskeleton 3.0207 0.00807
Cellular_component Axon part 2.4846 0.00206
Cellular_component Ruffle 2.1639 0.00663
  1. RR relative risk is a measure of effect size describing the change of proportions between our selected set of genes and a given term
  2. Q value Q value is the result from the adjustment of P values in order to control the false discovery rate (FDR) using the Benjamini-Hochberg method