Fig. 3

Arthritic ApoE^−/− mice have increased F4/80⁺ foam cells. a Photomicrographs of F4/80-stained extra-articular tissue, synovial lining and pannus of arthritic C57BL/6 (control, n = 10) and ApoE^−/− (n = 6) mice. Squares delineate area of higher magnification shown below the respective image. b Immunohistopathological scores for F4/80⁺ total cells, F4/80⁺ cells within synovial lining and F4/80⁺ cells within the pannus from control and ApoE^−/−mice. F4/80⁺ foam cells within each of these categories are subsequently quantified from the mice described above. Data are represented as mean ± SEM. Asterisk denotes statistically significant differences: ***p < 0.001. SL synovial lining, P pannus, arrowheads foamy macrophages