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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages

Fig. 1

Activation of inflammasome in monocytes from active SLE patients. a, b PBMCs were isolated from active SLE patients (n = 72) or healthy controls (HC) (n = 36). The activation of caspase-1 in monocytes was measured by flow cytometry and cells were gated on monocyte population. The activation of caspase-1 in SLE patients was significantly higher than that of healthy controls. c, d Serum levels of IL-1β and IL-17A were significantly higher in active SLE patients than that of healthy controls. e Serum level of IL-1β was correlated with MFI of active caspase-1. f MFI of active caspase-1 was correlated with serum level of anti-dsDNA antibody. g MFI of active caspase-1 was correlated with SLEDAI. **p < 0.001, vs HC. α-dsDNA anti-dsDNA antibodies

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