Fig. 7From: Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIVSP induces cleavage of CD163 in monocytes. sCD163 was measured by ELISA in the supernatant of freshly isolated human monocytes treated with SP and aprepitant as indicated. a Time course of cells treated with varying doses of SP as indicated. *p < 0.001 control versus 5 and 10 μM of SP. b Cells were pre-incubated with aprepitant (10 μM) for 30 min and then treated with SP (5 μM) for 60 min. *p < 0.001 SP versus control, p = 0.004 SP versus SP + aprepitant. Results are presented as mean ± SD from three independent experimentsBack to article page