NER genotypes | No. of patients | DFS | OS | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Progression | Univariate analysis | Multivariate analysis* | Death | Univariate analysis | Multivariate analysis* | ||||||
No. (%) | HR (95Â % CI) | P value | HR (95Â % CI) | P value | No. (%) | HR (95Â % CI) | P value | HR (95Â % CI) | P value | ||
ERCC5 rs2094258 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 CC | 108 | 53 (49.1) | 1.00 |  | 1.00 |  | 42 (38.9) | 1.00 |  | 1.00 |  |
 CT | 181 | 128 (70.7) | 1.78 (1.29–2.46) | 0.0004 | 1.70 (1.23–2.36) | 0.001 | 118 (65.2) | 2.06 (1.45–2.93) | <0.0001 | 1.98 (1.38–2.83) | 0.0002 |
 TT | 55 | 39 (70.9) | 1.72 (1.14–2.61) | 0.010 | 1.63 (1.07–2.48) | 0.021 | 36 (65.5) | 2.07 (1.32–2.23) | 0.001 | 2.02 (1.29–3.16) | 0.002 |
 CT+TT | 236 | 167 (70.8) | 1.76 (1.30–2.41) | 0.0003 | 1.68 (1.23–2.31) | 0.012 | 154 (65.3) | 2.06 (1.46–2.90) | <0.0001 | 1.99 (1.40–2.81) | 0.0001 |
 Trend test |  |  |  | 0.002 |  | 0.0007 |  |  | 0.0002 |  | 0.0005 |
 CC+CT | 289 | 181 (62.6) | 1.00 |  | 1.00 |  | 160 (55.4) | 1.00 |  | 1.00 |  |
 TT | 55 | 39 (70.9) | 1.19 (0.84–1.68) | 0.331 | 1.16 (0.82–1.64) | 0.415 | 36 (65.5) | 1.28 (0.89–1.84) | 0.178 | 1.29 (0.90–1.86) | 0.171 |
ERCC5 rs2296147 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 TT | 244 | 160 (65.6) | 1.00 |  | 1.00 |  | 145 (59.4) | 1.00 |  | 1.00 |  |
 TC | 91 | 56 (61.5) | 0.91 (0.67–1.23) | 0.524 | 0.91 (0.67–1.24) | 0.563 | 49 (53.9) | 0.87 (0.63–1.21) | 0.411 | 0.92 (0.66–1.29) | 0.603 |
 CC | 9 | 4 (44.4) | 0.52 (0.19–1.42) | 0.201 | 0.49 (0.18–1.34) | 0.165 | 2 (22.2) | 0.26 (0.06–1.05) | 0.058 | 0.27 (0.07–1.09) | 0.066 |
 TC+CC | 100 | 60 (60.0) | 0.86 (0.64–1.16) | 0.333 | 0.87 (0.64–1.17) | 0.345 | 51 (51.0) | 0.80 (0.58–1.10) | 0.172 | 0.84 (0.61–1.16) | 0.289 |
 Trend test |  |  |  | 0.214 |  | 0.206 |  |  | 0.067 |  | 0.120 |
 TT+CT | 335 | 216 (64.5) | 1.00 |  | 1.00 |  | 194 (57.9) | 1.00 |  | 1.00 |  |
 CC | 9 | 4 (4.4) | 0.54 (0.20–1.45) | 0.219 | 0.51 (0.19–1.37) | 0.180 | 2 (22.2) | 0.27 (0.07–1.08) | 0.065 | 0.28 (0.07–1.12) | 0.071 |
ERCC5 rs873601 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 AA | 56 | 29 (51.8) | 1.00 |  |  |  | 22 (39.3) |  |  |  |  |
 GA | 189 | 126 (66.7) | 1.58 (1.05–2.36) | 0.027 | 1.63 (1.08–2.47) | 0.021 | 112 (59.3) | 1.83 (1.16–2.89) | 0.010 | 1.89 (1.19–3.02) | 0.008 |
 GG | 99 | 65 (65.7) | 1.56 (1.01–2.42) | 0.047 | 1.51 (0.97–2.34) | 0.069 | 62 (62.6) | 1.99 (1.22–3.24) | 0.006 | 1.93 (1.18–3.16) | 0.009 |
 GA+GG | 288 | 191 (66.3) | 1.57 (1.06–2.32) | 0.024 | 1.59 (1.06–2.37) | 0.024 | 174 (39.3) | 1.89 (1.21–2.94) | 0.005 | 1.91 (1.21–2.99) | 0.0005 |
 Trend test |  |  |  | 0.084 |  | 0.146 |  |  | 0.011 |  | 0.021 |
 AA+GA | 245 | 155 (63.3) | 1.00 |  |  |  | 134 (54.7) | 1.00 |  |  |  |
 GG | 99 | 65 (65.7) | 1.09 (0.82–1.46) | 0.536 | 1.04 (0.77–1.39) | 0.803 | 62 (62.6) | 1.23 (0.91–1.67) | 0.168 | 1.18 (0.87–1.60) | 0.297 |
ERCC2 rs238406 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 GG | 102 | 58 (56.9) | 1.00 |  | 1.00 |  | 50 (49.0) | 1.00 |  | 1.00 |  |
 GT | 158 | 101 (63.9) | 1.16 (0.84–1.61) | 0.361 | 1.15 (0.83–1.60) | 0.403 | 87 (55.1) | 1.21 (0.85–1.71) | 0.256 | 1.23 (0.87–1.75) | 0.247 |
 TT | 84 | 61 (72.6) | 1.59 (1.11–2.28) | 0.012 | 1.56 (1.08–2.24) | 0.017 | 59 (70.2) | 1.76 (1.21–2.57) | 0.003 | 1.72 (1.18–2.52) | 0.005 |
 GT+TT | 242 | 162 (66.9) | 1.29 (0.96–1.75) | 0.094 | 1.28 (0.94–1.73) | 0.115 | 146 (60.3) | 1.38 (1.00–1.91) | 0.049 | 1.40 (1.01–1.93) | 0.044 |
 Trend test |  |  |  | 0.013 |  | 0.019 |  |  | 0.004 |  | 0.005 |
 GG+GT | 260 | 159 (61.2) | 1.00 |  | 1.00 |  | 137 (52.7) | 1.00 |  | 1.00 |  |
 TT | 84 | 61 (72.6) | 1.45 (1.08–1.95) | 0.014 | 1.43 (1.06–1.93) | 0.020 | 59 (70.2) | 1.57 (1.15–2.13) | 0.004 | 1.52 (1.12–2.03) | 0.008 |
XPC rs1870134 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 GG | 181 | 111 (61.3) |  |  |  |  | 94 (51.9) | 1.00 |  | 1.00 |  |
 GC | 144 | 95 (66.0) | 1.08 (0.82–1.41) | 0.605 | 1.10 (0.83–1.46) | 0.495 | 89 (61.8) | 1.21(0.91–1.62) | 0.192 | 1.25 (0.93–1.68) | 0.137 |
 CC | 18 | 14 (73.7) | 1.67 (0.96–2.92) | 0.070 | 1.41 (0.80–2.48) | 0.235 | 13 (68.4) | 1.77 (0.99–3.17) | 0.053 | 1.52 (0.84–2.75) | 0.164 |
 GC+CC | 163 | 109 (66.9) | 1.13 (0.87–1.47) | 0.374 | 1.13 (0.87–1.48) | 0.356 | 102 (62.6) | 1.26 (0.96–1.67) | 0.101 | 1.28 (0.96–1.70) | 0.088 |
 Trend test |  |  |  | 0.171 |  | 0.242 |  |  | 0.045 |  | 0.066 |
 GG+GC | 325 | 206 (63.4) | 1.00 |  | 1.00 |  | 183 (56.3) | 1.00 |  | 1.00 |  |
 CC | 19 | 14 (73.7) | 1.62 (0.94–2.79) | 0.081 | 1.35 (0.78–2.35) | 0.285 | 13 (68.4) | 1.62 (0.92–2.85) | 0.093 | 1.38 (0.78–2.45) | 0.274 |
XPC rs2228001 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 TT | 139 | 87 (62.6) | 1.00 |  | 1.00 |  | 77 (55.4) | 1.00 |  | 1.00 |  |
 TG | 155 | 101 (65.2) | 1.10 (0.82–1.46) | 0.537 | 1.19 (0.89–1.59) | 0.250 | 89 (57.4) | 1.05 (0.77–1.42) | 0.758 | 1.15 (0.84–1.57) | 0.377 |
 GG | 50 | 32 (64.0) | 1.18 (0.79–1.77) | 0.418 | 1.29 (0.85–1.96) | 0.238 | 30 (60.0) | 1.25 (0.82–1.91) | 0.295 | 1.36 (0.88–2.12) | 0.171 |
 TG+GG | 205 | 133 (64.9) | 1.12 (0.85–1.46) | 0.432 | 1.21 (0.92–1.59) | 0.181 | 119 (58.0) | 1.09 (0.82–1.46) | 0.539 | 1.19 (0.89–1.60) | 0.241 |
 Trend test |  |  |  | 0.713 |  | 0.593 |  |  | 0.386 |  | 0.282 |
 TT+TG | 294 | 188 (64.0) | 1.00 |  | 1.00 |  | 166 (56.5) | 1.00 |  | 1.00 |  |
 GG | 50 | 32 (64.0) | 0.89 (0.61–1.29) | 0.531 | 1.17 (0.80–1.73) | 0.418 | 30 (60.0) | 1.22 (0.83–1.80) | 0.313 | 1.26 (0.84–1.89) | 0.263 |
NRG** | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0 | 37 | 18 (48.7) | 1.00 |  | 1.00 |  | 12 (32.4) | 1.00 |  | 1.00 |  |
 1 | 63 | 30 (47.6) | 0.97 (0.54–1.17) | 0.789 | 1.09 (0.60–1.98) | 0.920 | 25 (39.7) | 1.22 (0.61–1.42) | 0.578 | 1.38 (0.69–2.79) | 0.365 |
 2 | 187 | 127 (67.9) | 1.32 (1.03–1.69) | 0.030 | 1.32 (1.03–1.71) | 0.021 | 115 (61.5) | 1.53 (1.14–2.06) | 0.005 | 1.55 (1.15–2.10) | 0.005 |
 3 | 57 | 45 (79.0) | 1.34 (1.12–1.61) | 0.002 | 1.34 (1.11–1.61) | 0.0009 | 44 (77.2) | 1.51 (1.22–1.87) | <0.0002 | 1.51 (1.22–1.88) | 0.0002 |
 Trend test |  |  |  | <0.0001 |  | <0.0001 |  |  | <0.0001 |  | <0.0001 |
 0–1 | 100 | 48 (48.0) | 1.00 |  | 1.00 |  | 37 (37.0) | 1.00 |  | 1.00 |  |
 2–3 | 244 | 172 (70.5) | 1.69 (1.22–2.35) | 0.002 | 1.67 (1.20–2.34) | 0.003 | 159 (65.2) | 1.84 (1.32–2.58) | 0.0004 | 1.77 (1.29–2.50) | 0.001 |