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Table 1 Associations of demographics and clinicopathological characteristics with DFS and OS of Chinese ESCC patients

From: Genetic variants of DNA repair genes predict the survival of patients with esophageal squamous cell cancer receiving platinum-based adjuvant chemotherapy

Parameters No. of patients DFS OS
Progression Univariate analysis Multivariate analysis* Death Univariate analysis Multivariate analysis*
No. (%) HR (95 % CI) P value HR (95 % CI) P value No. (%) HR (95 % CI) P value HR (95 % CI) P value
Age     0.287   0.295    0.123   0.087
 <60 181 110 (60.8) 1.00   1.00   95 (52.5) 1.00   1.00  
 ≥60 163 110 (67.5) 1.15 (0.89–1.50)   1.15 (0.88–1.51)   101 (91.8) 1.25 (0.94–1.65)   1.28 (0.96–1.70)  
Sex     0.083   0.816    0.189   0.847
 Male 295 194 (65.8) 1.00   1.00   173 (58.6) 1.00   1.00  
 Female 49 26 (53.1) 0.69 (0.46–1.05)   0.82 (0.51–1.30)   23 (46.9) 0.72 (0.48–1.15)   0.95 (0.58–1.56)  
Smoking     0.080   0.250    0.035   0.046
 Never 122 72 (59.0) 1.00   1.00   61 (50.0) 1.00   1.00  
 Yes 222 148 (66.7) 1.28 (0.97–1.70)   1.22 (0.87–1.70)   135 (60.8) 1.39 (1.02–1.88)   1.44 (1.01–2.07)  
Drinking     0.192   0.970    0.302   0.855
 No 171 103 (60.2) 1.00   1.00   92 (53.8) 1.00   1.00  
 Yes 173 117 (67.6) 1.19 (0.92–1.56)   1.01 (0.75–1.36)   104 (60.1) 1.16 (0.88–1.54)   0.97 (0.71–1.33)  
Vessel invasion     0.0006   0.015    0.0002   0.005
 No 243 142 (58.44) 1.00   1.00   122 (50.21) 1.00   1.00  
 Yes 101 78 (72.23) 1.61 (1.22–2.13)   1.44 (1.07–1.94)   74 (73.27) 1.72 (1.29–2.30)   1.56 (1.14–2.12)  
Neural invasion     0.831   0.481    0.505   0.787
 No 254 161 (63.39) 1.00   1.00   141 (55.51) 1.00   1.00  
 Yes 90 59 (65.56) 1.03 (0.77–1.39)   0.90 (0.66–1.22)   55 (61.11) 1.11 (0.81–1.52)   0.96 (0.69–1.32)  
TNM stage     <0.0001   0.007    0.0003   0.021
 II 116 58 (50.00) 1.00   1.00   52 (44.83) 1.00   1.00  
 III 228 162 (71.05) 1.80 (1.33–2.43)   1.55 (1.13–2.12)   144 (63.16) 1.78 (1.29–2.44)   1.49 (1.06–2.08)  
Lymphadenectomy     0.003   0.035    0.006   0.066
 Two fields 281 172 (61.21) 1.00   1.00   153 (54.45) 1.00   1.00  
 Three fields 63 48 (76.19) 1.62 (1.18–2.24)   1.42 (1.03–1.97)   43 (68.25) 1.61 (1.14–2.25)   1.38 (0.98–1.95)  
  1. * Adjusted for all parameters listed in Table 1