Table 1 Associations of demographics and clinicopathological characteristics with DFS and OS of Chinese ESCC patients
Parameters | No. of patients | DFS | OS | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Progression | Univariate analysis | Multivariate analysis* | Death | Univariate analysis | Multivariate analysis* | ||||||
No. (%) | HR (95Â % CI) | P value | HR (95Â % CI) | P value | No. (%) | HR (95Â % CI) | P value | HR (95Â % CI) | P value | ||
Age | Â | Â | Â | 0.287 | Â | 0.295 | Â | Â | 0.123 | Â | 0.087 |
 <60 | 181 | 110 (60.8) | 1.00 |  | 1.00 |  | 95 (52.5) | 1.00 |  | 1.00 |  |
 ≥60 | 163 | 110 (67.5) | 1.15 (0.89–1.50) |  | 1.15 (0.88–1.51) |  | 101 (91.8) | 1.25 (0.94–1.65) |  | 1.28 (0.96–1.70) |  |
Sex | Â | Â | Â | 0.083 | Â | 0.816 | Â | Â | 0.189 | Â | 0.847 |
 Male | 295 | 194 (65.8) | 1.00 |  | 1.00 |  | 173 (58.6) | 1.00 |  | 1.00 |  |
 Female | 49 | 26 (53.1) | 0.69 (0.46–1.05) |  | 0.82 (0.51–1.30) |  | 23 (46.9) | 0.72 (0.48–1.15) |  | 0.95 (0.58–1.56) |  |
Smoking | Â | Â | Â | 0.080 | Â | 0.250 | Â | Â | 0.035 | Â | 0.046 |
 Never | 122 | 72 (59.0) | 1.00 |  | 1.00 |  | 61 (50.0) | 1.00 |  | 1.00 |  |
 Yes | 222 | 148 (66.7) | 1.28 (0.97–1.70) |  | 1.22 (0.87–1.70) |  | 135 (60.8) | 1.39 (1.02–1.88) |  | 1.44 (1.01–2.07) |  |
Drinking | Â | Â | Â | 0.192 | Â | 0.970 | Â | Â | 0.302 | Â | 0.855 |
 No | 171 | 103 (60.2) | 1.00 |  | 1.00 |  | 92 (53.8) | 1.00 |  | 1.00 |  |
 Yes | 173 | 117 (67.6) | 1.19 (0.92–1.56) |  | 1.01 (0.75–1.36) |  | 104 (60.1) | 1.16 (0.88–1.54) |  | 0.97 (0.71–1.33) |  |
Vessel invasion | Â | Â | Â | 0.0006 | Â | 0.015 | Â | Â | 0.0002 | Â | 0.005 |
 No | 243 | 142 (58.44) | 1.00 |  | 1.00 |  | 122 (50.21) | 1.00 |  | 1.00 |  |
 Yes | 101 | 78 (72.23) | 1.61 (1.22–2.13) |  | 1.44 (1.07–1.94) |  | 74 (73.27) | 1.72 (1.29–2.30) |  | 1.56 (1.14–2.12) |  |
Neural invasion | Â | Â | Â | 0.831 | Â | 0.481 | Â | Â | 0.505 | Â | 0.787 |
 No | 254 | 161 (63.39) | 1.00 |  | 1.00 |  | 141 (55.51) | 1.00 |  | 1.00 |  |
 Yes | 90 | 59 (65.56) | 1.03 (0.77–1.39) |  | 0.90 (0.66–1.22) |  | 55 (61.11) | 1.11 (0.81–1.52) |  | 0.96 (0.69–1.32) |  |
TNM stage | Â | Â | Â | <0.0001 | Â | 0.007 | Â | Â | 0.0003 | Â | 0.021 |
 II | 116 | 58 (50.00) | 1.00 |  | 1.00 |  | 52 (44.83) | 1.00 |  | 1.00 |  |
 III | 228 | 162 (71.05) | 1.80 (1.33–2.43) |  | 1.55 (1.13–2.12) |  | 144 (63.16) | 1.78 (1.29–2.44) |  | 1.49 (1.06–2.08) |  |
Lymphadenectomy | Â | Â | Â | 0.003 | Â | 0.035 | Â | Â | 0.006 | Â | 0.066 |
 Two fields | 281 | 172 (61.21) | 1.00 |  | 1.00 |  | 153 (54.45) | 1.00 |  | 1.00 |  |
 Three fields | 63 | 48 (76.19) | 1.62 (1.18–2.24) |  | 1.42 (1.03–1.97) |  | 43 (68.25) | 1.61 (1.14–2.25) |  | 1.38 (0.98–1.95) |  |