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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Impaired CD8+ T cell responses upon Toll-like receptor activation in common variable immunodeficiency

Fig. 5

Impaired CD38− or CD38+ CD8+ T cell polyfunctionality induced by SEB in CVID. The combinations of IFN-γ, IL-10, IL-17a, IL-22, and TNF secreted by (a) CD4+ and (b) CD8+ T cells in the presence or absence of CD38 expression, induced by TLR2 (Pam3CSK4), TLR3 (Poly-RIG), TLR7/8 (CL097), PMA/ionomycin or SEB, from HC (n = 16) and CVID (n = 16) individuals were evaluated by a Boolean strategy. Frequencies of stimulated CD4+ or CD8+ T cells were subtracted from baseline values. Data represent the median and the interquartile range. *p ≤ 0.05

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