Fig. 1

Altered exhaustion/activation marker expression on T cells and frequency of regulatory T cells in CVID. PBMCs from healthy control (HC, n = 16) and CVID patients (n = 14) were assessed for (a) PD-1 and (b) CD127 expression in CD4⁺ and CD8⁺ T cells, according to the maturation stage, and for the presence (+) or absence (−) of splenomegaly (spl); (c) follicular T cells (CD3⁺ CD4⁺ CXCR5⁺ PD-1⁺ ICOS⁺) and (d) naïve regulatory T cells (CD3⁺ CD4⁺ CD45RA⁺ Foxp3⁺) were determined by flow cytometry. Data represent the median and the interquartile range. *p ≤ 0.05, **p ≤ 0.001, ***p ≤ 0.0001