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Table 1 Molecular functions of differentially expressed proteins spots in shunt compared to sham

From: Proteomic analysis of short-term preload-induced eccentric cardiac hypertrophy

Protein

Spot number

Average sham

Average shunt

T test

Regulation (%)

Cytoskeletal and contractile proteins

 Actin, aortic smooth muscle

5

0266

0126

0007

−53

 Actin, cytoplasmic 1

22

0085

0188

0030

121

 Myosin-6

20

0010

0026

0029

167

 Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

14

0743

0347

0021

−53

 Tropomyosin alpha-1 chain

21

0037

0097

0030

162

 Tubulin beta-2C chain

4

0010

0026

0006

166

Metabolism

 β-enolase

3

0052

0187

0005

263

 β-enolase

34

0057

0211

0047

271

 Delta-aminolevulinic acid dehydratase

25

0018

0121

0037

571

 L-lactate dehydrogenase B chain

13

0059

0028

0018

−52

Mitochondrial proteins

 ATP synthase subunit alpha, mitochondrial (Complex V)

30

0297

0618

0041

108

 ATP synthase subunit d, mitochondrial (Complex V)

31

0266

0068

0042

−74

 ATP synthase subunit alpha, mitochondrial (Complex V)

33

0045

0099

0047

119

 ATP synthase subunit beta (Complex V)

12

0069

0147

0023

115

 ATP synthase subunit beta, mitochondrial (Complex V)

38

0044

0086

0018

96

 Cytochrome b-c1 complex subunit 1 (Complex III)

7

0089

0027

0012

−69

 Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III)

32

0005

0025

0043

368

 Electron transfer flavoprotein subunit beta

8

0094

0249

0015

164

 60 kDa heat shock protein, mitochondrial

24

0041

0081

0034

97

 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

16

0146

0071

0025

−51

 Thioredoxin-dependent peroxide reductase, mitochondrial

35

0016

0004

0048

−74

Others

 α-1-antitrypsin 1-2

1

0813

0345

0002

−58

 COP9 signalosome complex subunit 4

18

0049

0113

0026

132

 Heat shock cognate 71 kDa protein

11

0061

0013

0039

−79

 Polymerase I and transcript release factor

28

0304

0657

0039

116