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Table 3 Metabolites significantly correlating with assay read-out overlap with metabolites significantly correlating with galactose

From: Measurement of 1,5-anhydroglucitol in blood and saliva: from non-targeted metabolomics to biochemical assay

Metabolite

Biochemical class

Correlation with assay read-out

Correlation with galactose

lm(AG_Sal_H ~ met + galactose)

r2

p

r2

p

p

Galactose

Carbohydrate

0.704

4.7 × 10−23

N-acetylglucosamine

Carbohydrate

0.436

9.2 × 10−12

0.787

7.8 × 10−29

2.5 × 10−03

Fucose

Carbohydrate

0.376

5.4 × 10−10

0.542

3.1 × 10−15

0.99

Xylose

Carbohydrate

0.318

2.5 × 10−08

0.506

6.1 × 10−14

0.47

Mannose

Carbohydrate

0.276

2.3 × 10−07

0.396

1.4 × 10−10

0.97

O-acetylserine

Amino acid

0.355

1.9 × 10−06

0.524

7.9 × 10−10

0.84

Putrescine

Amine

0.234

2.5 × 10−06

0.451

3.0 × 10−12

0.09

Ribose

Carbohydrate

0.232

2.7 × 10−06

0.403

9.0 × 10−11

0.31

1,2-propanediol

Lipid

0.200

1.5 × 10−05

0.279

2.0 × 10−07

0.89

X-14904

Unknown

0.186

3.0 × 10−05

NS

NS

2.2 × 10−04

X-18059

Unknown

0.186

3.1 × 10−05

NS

NS

5.9 × 10−04

Lysylproline

Peptide

0.185

3.3 × 10−05

0.413

4.5 × 10−11

0.02

  1. The association trend was positive for all significantly correlating metabolites. We analysed correlation of those metabolites with galactose, which correlation with assay read-out was the strongest. No significance in correlation between metabolites and galactose is expressed as NS. We applied linear regression (lm) of 1,5-AG measured with Glycomark (AG_Sal_H) against 1,5-AG measured on non-targeted metabolomics platform (AG_Sal_M) and corrected on the covariate (met), listed in the “Metabolite name” column. Metabolites with similar chemical structure to 1,5-AG are highlighted in italics