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Table 3 Multivariate Cox regression models for combined NB validation cohorts based on OS considering single prognostic marker and the 18-gene Stage4 NB risk score

From: An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma

Marker Hazard ratio 95 % CI P value
Validation cohort 1 + 2 (n = 241)
Age (≥18 vs < 18 months) 2.64 1.579–4.414 0.00020
MYCN (amplified vs not amplified) 2.549 1.744–3.727 0.000001
18-gene Stage 4 NB risk score (high vs low risk score groups) 2.237 1.098–4.554 0.027
  1. OS overall survival, N/S not significant, NB neuroblastoma