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Table 1 Clinical features of stage 4 NB patients

From: An 18 gene expression-based score classifier predicts the clinical outcome in stage 4 neuroblastoma

Variables

Seeger cohorta

Versteeg cohortb

Validation cohort 1c

Validation cohort 2d

n = 102

n = 40

n = 214

n = 27

Sex

 Male

N/A

24 (60 %)

122 (60.1)

13 (48.1)

 Female

N/A

16 (40 %)

81 (39.9)

14 (51.8)

 N/A

  

12

 

Age

 Median (years)

 

2.5

2.7

2.6

 <18 months

N/A

8 (20.0 %)

68 (31.8 %)

8 (29.6)

 ≥18 months

N/A

32 (30.0 %)

146 (68.2 %)

19 (70.4)

MYCN amplification

 Yes

0 (0 %)

15 (37.5 %)

68 (31.9 %)

14 (51.8)

 No

102 (100 %)

25 (62.5 %)

145 (68.1 %)

13 (48.1)

  1. N/A not available, NB neuroblastoma
  2. a,b,cMicroarray gene expression data downloaded from GEO datasets (GSE16254, GSE16476, GSE45547)
  3. dMicroarray gene expression data produced from a new cohort of stage 4 tumors (GSE79910)