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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters

Fig. 6

Moderate dose-dependent antibody response to CRAd-S-pk7 administration. Serum anti-AdE1a antibody titer was determined in both male and female hamsters (a, b) on days 6, 34, and 62 after initial treatment for the doses shown (n = 5 animals/group). The analyzed measurements are shown as group geometric mean titers in the log10 scale. One-way ANOVA and Kruskal–Wallis test were used for comparison of E1A antibody titers between animals from vehicle control (G2) and treatment (G3-5) groups; ***P < 0.001. Values of the group geometric mean titer were rounded to the nearest whole number. For the calculation of the geometric mean, when the titer was <400 (the lower limit of detection in this assay), a value of 40 (1/10th of 400) was used

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