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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters

Fig. 3

Mean vector DNA in the brains. Brain tissues of male and female hamsters were analyzed for the presence of CRAd-S-pk7 DNA post virus injection. Intracerebral CRAd-S-pk7 DNA was found 6 days after injection in both sexes (G2 vs. G3/4/5, P < 0.0001, one-way ANOVA), whereas DNA detection decreased gradually by days 32 and 64 by at least one order of magnitude (G2 vs. G3/4 for male hamsters, P < 0.0001, one-way ANOVA, and G2 vs. G5 for female hamsters, P < 0.0001, one-way ANOVA). The analyzed measurements are shown as log10 (viral copies/ng × 1000). Each plot represents the average of five animals/sex/group/time point and standard deviations were indicated by error bars. One-way ANOVA and Kruskal–Wallis test were used for comparison between vehicle (G2) and treated (G3-5) groups. ***P < 0.001

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