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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Single dose GLP toxicity and biodistribution study of a conditionally replicative adenovirus vector, CRAd-S-pk7, administered by intracerebral injection to Syrian hamsters

Fig. 2

Body weight and food consumption for male and female hamsters. Administration of CRAd-S-pk7 had no significant effect on body weight or food consumption for male hamsters (P > 0.05, one-way ANOVA). In the female group, a significant difference was noted concerning decreased food consumption on days 1–8: groups 2 vs. 4, P 0.032; groups 2 vs. 5, P 0.027; days 8–15: groups 2 vs. 5, P 0.009; days 15–22: groups 3 vs. 5, P 0.01; one-way ANOVA. However, this tendency was not considered to be biologically significant. The analyzed measurements are shown as g for body weight and g/animal/day for food consumption. Each plot represents the average of 5–10 animals/sex/group/time point and standard deviations were indicated by error bars. One-way ANOVA and Kruskal–Wallis test were used for comparison between vehicle (G2) and treated (G3-5) groups. *P < 0.05

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