Longitudinal brain structural alterations and systemic inflammation in obstructive sleep apnea before and after surgical treatment

Table 4 Correlation between regional GMV and clinical disease severity (PSG parameters and leukocyte apoptosis)

Regional GMV differences between OSA_baseline and controls
		AHI	Average O₂ saturation	De-saturation index	Granulocyte early apoptosis	Monocyte early apoptosis	Total leukocyte early apoptosis
Left Anterior Cingulate Gyrus	r	−0.337	0.140	−0.217	−0.181	−0.259	−0.282
Left Anterior Cingulate Gyrus	p	0.059	0.444	0.234	0.321	0.153	0.117
Right Insula	r	0.516	−0.574	0.508	0.419	0.364	0.405
Right Insula	p	0.003*	0.001*	0.003*	0.017*	0.041*	0.022*

Regional GMV differences between OSA_baseline and OSA_follow
		∆AHI	∆Average O₂ saturation	∆De-saturation index	∆Granulocyte early apoptosis	∆Monocyte early apoptosis	∆Total leukocyte early apoptosis
Left Hipp/PCG/Precuneus	r	−0.035	−0.141	0.116	0.521	0.407	0.562
Left Hipp/PCG/Precuneus	p	0.885	0.565	0.637	0.022*	0.084	0.012*
Left STG/IFG/Insula	r	0.231	0.106	0.096	0.058	−0.199	−0.075
Left STG/IFG/Insula	p	0.341	0.665	0.696	0.812	0.415	0.760
Left cerebellum	r	0.201	0.311	0.167	−0.376	−0.438	−0.442
Left cerebellum	p	0.410	0.195	0.495	0.113	0.060	0.058

Anatomical regions: Hipp/PCG/Precuneus, hippocampus/posterior cingulate gyrus/precuneus; STG/IFG/Insula, superior temporal gyrus/inferior frontal gyrus/insula
AHI apnea-hypopnea index; GMV gray matter volume; OSA obstructive sleep apnea; PSG polysomnography
* Statistical threshold was set at p < 0.05

ISSN: 1479-5876