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Table 4 Correlation between regional GMV and clinical disease severity (PSG parameters and leukocyte apoptosis)

From: Longitudinal brain structural alterations and systemic inflammation in obstructive sleep apnea before and after surgical treatment

Regional GMV differences between OSAbaseline and controls
   AHI Average O2 saturation De-saturation index Granulocyte early apoptosis Monocyte early apoptosis Total leukocyte early apoptosis
Left Anterior Cingulate
Gyrus
r −0.337 0.140 −0.217 −0.181 −0.259 −0.282
p 0.059 0.444 0.234 0.321 0.153 0.117
Right Insula r 0.516 −0.574 0.508 0.419 0.364 0.405
p 0.003* 0.001* 0.003* 0.017* 0.041* 0.022*
Regional GMV differences between OSAbaseline and OSAfollow
   ∆AHI ∆Average O2 saturation ∆De-saturation index ∆Granulocyte early apoptosis ∆Monocyte early apoptosis ∆Total leukocyte early apoptosis
Left Hipp/PCG/Precuneus r −0.035 −0.141 0.116 0.521 0.407 0.562
p 0.885 0.565 0.637 0.022* 0.084 0.012*
Left STG/IFG/Insula r 0.231 0.106 0.096 0.058 −0.199 −0.075
p 0.341 0.665 0.696 0.812 0.415 0.760
Left cerebellum r 0.201 0.311 0.167 −0.376 −0.438 −0.442
p 0.410 0.195 0.495 0.113 0.060 0.058
  1. Anatomical regions: Hipp/PCG/Precuneus, hippocampus/posterior cingulate gyrus/precuneus; STG/IFG/Insula, superior temporal gyrus/inferior frontal gyrus/insula
  2. AHI apnea-hypopnea index; GMV gray matter volume; OSA obstructive sleep apnea; PSG polysomnography
  3. * Statistical threshold was set at p < 0.05