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Table 2 Cognitive test results of OSA patients and control subjects

From: Longitudinal brain structural alterations and systemic inflammation in obstructive sleep apnea before and after surgical treatment

Neuropsychological tests NC (n = 15) OSAbaseline
(n = 21)
OSAfollow
(n = 21)
p value
NC vs. OSAbaseline NC vs. OSAfollow OSAbaseline vs. OSAfollow
Attention
 Mental control (CASI) 9.53 (0.99) 9.40 (1.70) 9.50 (1.10) 0.664 0.908 0.776
 Attention (CASI) 7.73 (0.59) 7.65 (0.81) 7.60 (0.68) 0.999 0.631 0.716
 Orientation (CASI) 17.93 (0.26) 17.50 (1.82) 17.85 (0.49) 0.366 0.908 0.427
 Processing speed (WAIS-III) 105.67 (18.36) 100.55 (9.24) 108.55 (11.81) 0.280 0.757 <0.001*
Executive function
 Digit symbol (WAIS-III) 10.73 (3.04) 10.15 (1.81) 11.50 (2.50) 0.458 0.563 0.001*
 Abstraction (CASI) 9.73 (2.05) 10.25 (1.41) 10.70 (1.17) 0.645 0.145 0.119
Memory function
 Long-term memory (CASI) 10.00 (0.00) 10.00 (0.00) 10.00 (0.00) 1.000 1.000 1.000
 Short-term memory (CASI) 11.01 (1.01) 10.06 (1.56) 10.67 (1.50) 0.048* 0.398 0.175
Speech and language function
 Language (CASI) 9.78 (0.46) 9.95 (0.22) 9.95 (0.22) 0.218 0.320 1.000
 Verbal fluency (CASI) 9.27 (1.03) 8.95 (1.57) 9.30 (1.08) 0.265 0.550 0.330
Visuo-spatial function      
 Picture completion (WAIS-III) 11.20 (2.04) 11.10 (2.15) 11.55 (2.70) 0.495 0.911 0.206
 Letter number search (WAIS-III) 9.53 (3.27) 9.45 (2.09) 9.60 (3.27) 0.791 0.959 0.780
 Block design (WAIS-III) 11.47 (3.36) 11.10 (2.43) 11.95 (2.91) 0.455 0.846 0.015*
 Drawing (CASI) 9.87 (0.52) 9.95 (0.22) 9.90 (0.31) 0.693 0.901 0.577
CASI total score 94.85 (3.70) 94.01 (4.78) 95.47 (3.39) 0.357 0.809 0.163
BDI 8.47 (7.58) 8.50 (8.16) 4.70 (6.11) 0.675 0.048* 0.011*
  1. Data are presented as mean (SD)
  2. All data were compared by ANCOVA after controlling for age, sex, and BMI
  3. AHI apnea-hypopnea index; ANCOVA Analysis of Covariance; BDI Beck Depression Inventory; BMI body mass index, CASI Cognitive Ability Screening Instrument; NC normal controls; OSA obstructive sleep apnea; WAIS Wechsler Adult Intelligence Scale
  4. NC vs. OSAbaseline: Statistical comparison was performed by ANCOVA between controls and OSAbaseline
  5. NC vs. OSAfollow: Statistical comparison was performed by ANCOVA between controls and OSAfollow
  6. OSAbaseline vs. OSAfollow: Statistical comparison was performed by paired t test between OSAbaseline and OSAfollow
  7. * Statistical threshold was set at p < 0.05