TY - JOUR AU - Lin, Wei-Che AU - Huang, Chih-Cheng AU - Chen, Hsiu-Ling AU - Chou, Kun-Hsien AU - Chen, Pei-Chin AU - Tsai, Nai-Wen AU - Chen, Meng-Hsiang AU - Friedman, Michael AU - Lin, Hsin-Ching AU - Lu, Cheng-Hsien PY - 2016 DA - 2016/05/17 TI - Longitudinal brain structural alterations and systemic inflammation in obstructive sleep apnea before and after surgical treatment JO - Journal of Translational Medicine SP - 139 VL - 14 IS - 1 AB - Systemic inflammation, neurocognitive impairments, and morphologic brain changes are associated with obstructive sleep apnea (OSA). Understanding their longitudinal evolution and interactions after surgical treatment provides clues to the pathogenesis of cognitive impairment and its reversibility. In the present study, we investigate clinical disease severity, systemic inflammation, cognitive deficits, and corresponding gray matter volume (GMV) changes in OSA, and the modifications following surgery. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-016-0887-8 DO - 10.1186/s12967-016-0887-8 ID - Lin2016 ER -