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Table 3 Receiver operating characteristic curves

From: Serum microRNA-1233 is a specific biomarker for diagnosing acute pulmonary embolism

  AUC 95 % CI p Cut-off Sensitivity (%) 95 % CI Specificity (%) 95 % CI LR+ LR−
Acute PE vs. healthy
miR-27a 0.79 0.65–0.93 <0.01 0.63 67 50–83 92 75–100 8 0.4
miR-134 0.84 0.71–0.96 <0.001 0.51 83 70–97 83 58–100 5 0.2
miR-1233 0.91 0.82–0.99 <0.001 0.53 90 77–100 92 75–100 10.8 0.1
miR-27a + miR-134 0.88 0.78–0.98 <0.001 0.47 90 77–100 83 58–100 5.4 0.1
miR-27a + miR-1233 0.89 0.79–0.99 <0.001 0.48 97 90–100 83 58–100 5.8 0
miR-134 + miR-1233 0.88 0.77–0.98 <0.001 0.40 93 83–100 75 50–100 3.7 0
miR-27a + miR-134 + miR-1233 0.90 0.81–0.99 <0.001 0.50 90 80–100 83 58–100 5.4 0.1
Acute PE vs. NSTEMI
miR-27a 0.78 0.66–0.90 <0.001 0.46 63 43–80 89 79–100 5.9 0.4
miR-134 0.78 0.66–0.90 <0.001 0.74 83 70–97 64 46–82 2.3 0.3
miR-1233 0.95 0.89–1.00 <0.001 0.55 90 80–100 100 100–100 0.1
miR-27a + miR-134 0.80 0.68–0.91 <0.001 0.34 87 73–97 61 43–79 2.2 0.2
miR-27a + miR-1233 0.96 0.91–1.00 <0.001 0.69 90 77–100 100 100–100 0.1
miR-134 + miR-1233 0.95 0.89–1.00 <0.001 0.54 90 77–100 100 100–100 0.1
miR-27a + miR-134 + miR-1233 0.97 0.93–1.00 <0.001 0.71 90 77–100 100 100–100 0.1
Acute PE vs. DVT
miR-27a 0.83 0.67–0.98 <0.05 0.79 73 57–90 100 100–100 0.3
miR-134 0.84 0.72–0.99 <0.01 0.74 80 67–93 100 100–100 0.2
miR-1233 0.99 0.97–1.0 <0.001 0.72 97 90–100 100 100–100 0
miR-27a + miR-134 0.92 0.83–1.0 <0.001 0.63 87 73–97 100 100–100 0.1
miR-27a + miR-1233 0.99 0.97–1.0 <0.001 0.72 97 90–100 100 100–100 0
miR-134 + miR-1233 0.99 0.97–1.0 <0.001 0.72 97 90–100 100 90–100 0
miR-27a + miR-134 + miR-1233 0.99 0.97–1.0 <0.01 0.72 97 90–100 100 100–100 0
Acute PE vs. PHT
miR-27a 0.66 0.50–0.82 0.085 0.66 67 50–83 80 60–100 3.3 0.4
miR-134 0.67 0.51–0.83 0.062 0.61 70 53–87 73 47–93 2.6 0.4
miR-1233 0.91 0.83–0.99 <0.001 0.43 90 80–100 93 80–100 13.5 0.1
miR-27a + miR-134 0.66 0.50–0.82 0.085 0.59 70 53–87 73 47–93 2.6 0.4
miR-27a + miR-1233 0.92 0.84–1.0 <0.001 0.42 90 77–100 93 80–100 13.5 0.1
miR-134 + miR-1233 0.91 0.83–0.99 <0.001 0.42 90 77–100 93 80–100 13.5 0.1
miR-27a + miR-134 + miR-1233 0.90 0.81–0.99 <0.001 0.46 90 80–100 93 80–100 13.5 0.1
  1. Receiver operating characteristic (ROC) curves. Cut-off is defined as the Youden’s index which represents the point on the curve furthest away from the 45 degree line
  2. AUC area under the curve, CI confidence interval, LR + positive likelihood ratio, LR- negative likelihood ratio, miR microRNA, PE pulmonary embolism, NSTEMI acute non-ST segment myocardial infarction, DVT acute deep vein thrombosis without concomitant PE, PH chronic non-thromboembolic pulmonary hypertension