Serum microRNA-1233 is a specific biomarker for diagnosing acute pulmonary embolism

Kessler, Thorsten; Erdmann, Jeanette; Vilne, Baiba; Bruse, Petra; Kurowski, Volkhard; Diemert, Patrick; Schunkert, Heribert; Sager, Hendrik B.

doi:10.1186/s12967-016-0886-9

Journal of Translational Medicine

Table 3 Receiver operating characteristic curves

From: Serum microRNA-1233 is a specific biomarker for diagnosing acute pulmonary embolism

	AUC	95 % CI	p	Cut-off	Sensitivity (%)	95 % CI	Specificity (%)	95 % CI	LR+	LR−
Acute PE vs. healthy
miR-27a	0.79	0.65–0.93	<0.01	0.63	67	50–83	92	75–100	8	0.4
miR-134	0.84	0.71–0.96	<0.001	0.51	83	70–97	83	58–100	5	0.2
miR-1233	0.91	0.82–0.99	<0.001	0.53	90	77–100	92	75–100	10.8	0.1
miR-27a + miR-134	0.88	0.78–0.98	<0.001	0.47	90	77–100	83	58–100	5.4	0.1
miR-27a + miR-1233	0.89	0.79–0.99	<0.001	0.48	97	90–100	83	58–100	5.8	0
miR-134 + miR-1233	0.88	0.77–0.98	<0.001	0.40	93	83–100	75	50–100	3.7	0
miR-27a + miR-134 + miR-1233	0.90	0.81–0.99	<0.001	0.50	90	80–100	83	58–100	5.4	0.1
Acute PE vs. NSTEMI
miR-27a	0.78	0.66–0.90	<0.001	0.46	63	43–80	89	79–100	5.9	0.4
miR-134	0.78	0.66–0.90	<0.001	0.74	83	70–97	64	46–82	2.3	0.3
miR-1233	0.95	0.89–1.00	<0.001	0.55	90	80–100	100	100–100	∞	0.1
miR-27a + miR-134	0.80	0.68–0.91	<0.001	0.34	87	73–97	61	43–79	2.2	0.2
miR-27a + miR-1233	0.96	0.91–1.00	<0.001	0.69	90	77–100	100	100–100	∞	0.1
miR-134 + miR-1233	0.95	0.89–1.00	<0.001	0.54	90	77–100	100	100–100	∞	0.1
miR-27a + miR-134 + miR-1233	0.97	0.93–1.00	<0.001	0.71	90	77–100	100	100–100	∞	0.1
Acute PE vs. DVT
miR-27a	0.83	0.67–0.98	<0.05	0.79	73	57–90	100	100–100	∞	0.3
miR-134	0.84	0.72–0.99	<0.01	0.74	80	67–93	100	100–100	∞	0.2
miR-1233	0.99	0.97–1.0	<0.001	0.72	97	90–100	100	100–100	∞	0
miR-27a + miR-134	0.92	0.83–1.0	<0.001	0.63	87	73–97	100	100–100	∞	0.1
miR-27a + miR-1233	0.99	0.97–1.0	<0.001	0.72	97	90–100	100	100–100	∞	0
miR-134 + miR-1233	0.99	0.97–1.0	<0.001	0.72	97	90–100	100	90–100	∞	0
miR-27a + miR-134 + miR-1233	0.99	0.97–1.0	<0.01	0.72	97	90–100	100	100–100	∞	0
Acute PE vs. PHT
miR-27a	0.66	0.50–0.82	0.085	0.66	67	50–83	80	60–100	3.3	0.4
miR-134	0.67	0.51–0.83	0.062	0.61	70	53–87	73	47–93	2.6	0.4
miR-1233	0.91	0.83–0.99	<0.001	0.43	90	80–100	93	80–100	13.5	0.1
miR-27a + miR-134	0.66	0.50–0.82	0.085	0.59	70	53–87	73	47–93	2.6	0.4
miR-27a + miR-1233	0.92	0.84–1.0	<0.001	0.42	90	77–100	93	80–100	13.5	0.1
miR-134 + miR-1233	0.91	0.83–0.99	<0.001	0.42	90	77–100	93	80–100	13.5	0.1
miR-27a + miR-134 + miR-1233	0.90	0.81–0.99	<0.001	0.46	90	80–100	93	80–100	13.5	0.1

Receiver operating characteristic (ROC) curves. Cut-off is defined as the Youden’s index which represents the point on the curve furthest away from the 45 degree line
AUC area under the curve, CI confidence interval, LR + positive likelihood ratio, LR- negative likelihood ratio, miR microRNA, PE pulmonary embolism, NSTEMI acute non-ST segment myocardial infarction, DVT acute deep vein thrombosis without concomitant PE, PH chronic non-thromboembolic pulmonary hypertension

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