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Table 5 Univariate and multivariate Cox regression analyses of the prognostic variables in ESCC patients

From: PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma

Variables

Univariate analysis

Multivariate analysis

HR

95 % CI

P value

HR

95 % CI

P value

PFN2 expression (IS ≥ 4)

2.669

1.147

6.209

0.023*

2.465

1.020

5.955

0.045*

Gender (female)

1.734

0.910

3.303

0.094

1.574

0.780

3.176

0.206

Age (≥59 years)

0.882

0.483

1.870

0.950

1.027

0.481

2.191

0.945

Differentiation (well)

0.739

0.339

0.394

1.385

0.610

0.316

1.177

0.140

Invasion depth (T2–T3)

3.085

1.079

8.819

0.036*

1.087

0.271

4.368

0.906

Lymph node metastasis (yes)

1.147

0.590

2.228

0.686

1.198

0.595

2.415

0.613

TNM Stage (III + IV)

2.981

1.380

6.437

0.005*

3.037

1.094

8.833

0.033*

  1. HR hazard ratio, CI confidence interval, * P < 0.05