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Table 5 Univariate and multivariate Cox regression analyses of the prognostic variables in ESCC patients

From: PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma

Variables Univariate analysis Multivariate analysis
HR 95 % CI P value HR 95 % CI P value
PFN2 expression (IS ≥ 4) 2.669 1.147 6.209 0.023* 2.465 1.020 5.955 0.045*
Gender (female) 1.734 0.910 3.303 0.094 1.574 0.780 3.176 0.206
Age (≥59 years) 0.882 0.483 1.870 0.950 1.027 0.481 2.191 0.945
Differentiation (well) 0.739 0.339 0.394 1.385 0.610 0.316 1.177 0.140
Invasion depth (T2–T3) 3.085 1.079 8.819 0.036* 1.087 0.271 4.368 0.906
Lymph node metastasis (yes) 1.147 0.590 2.228 0.686 1.198 0.595 2.415 0.613
TNM Stage (III + IV) 2.981 1.380 6.437 0.005* 3.037 1.094 8.833 0.033*
  1. HR hazard ratio, CI confidence interval, * P < 0.05