TY - JOUR AU - Cui, Xiao-bin AU - Zhang, Shu-mao AU - Xu, Yue-xun AU - Dang, Hong-wei AU - Liu, Chun-xia AU - Wang, Liang-hai AU - Yang, Lan AU - Hu, Jian-ming AU - Liang, Wei-hua AU - Jiang, Jin-fang AU - Li, Na AU - Li, Yong AU - Chen, Yun-zhao AU - Li, Feng PY - 2016 DA - 2016/05/17 TI - PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma JO - Journal of Translational Medicine SP - 137 VL - 14 IS - 1 AB - Esophageal squamous cell carcinoma (ESCC) is one of the most aggressively malignant tumors with dismal prognosis. Profilin 2 (PFN2) is an actin-binding protein that regulates the dynamics of actin polymerization and plays a key role in cell motility. Recently, PFN2 have emerged as significant regulators of cancer processes. However, the clinical significance and biological function of PFN2 in ESCC remain unclear. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-016-0884-y DO - 10.1186/s12967-016-0884-y ID - Cui2016 ER -