| HER2-negative | HER2-positive | p value | ||
---|---|---|---|---|---|
Ki67 (%) | |||||
 Median (range) | 38 (1–90) | 40 (1–90) | 0.12 | ||
HER2 copies (FISH) | |||||
 Median (range) | 2 (1–9) | 13 (2–39) | <0.001 | ||
 Mean (±SD) | 3 (1) | 14 (8) |  | ||
HER2 ratio (FISH) | |||||
 Median (range) | 1 (1–8) | 5 (1–28) | <0.001 | ||
 Mean (±SD) | 1 (1) | 7 (4) |  | ||
CEN17 | |||||
 Median (range) | 2 (1–4) | 2 (1–4) | 0.006 | ||
 Mean (±SD) | 2 (1) | 2 (1) |  | ||
CEN8 | |||||
 Median (range) | 3 (1–9) | 2 (1–5) | 0.80 | ||
 Mean (±SD) | 3 (1) | 3 (1) |  | ||
CEN7 | |||||
 Median (range) | 2 (1–4) | 2 (1–5) | 0.50 | ||
 Mean (±SD) | 2 (1) | 2 (1) |  |
 | N | % | N | % | p value |
---|---|---|---|---|---|
IHC, categorical | |||||
 ER (N = 229) | |||||
  Negative | 16 | 17.8 | 60 | 43.2 | <0.001 |
  Positive | 74 | 82.2 | 79 | 56.8 |  |
 PgR (N = 229) | |||||
  Negative | 32 | 35.6 | 89 | 64 | <0.001 |
  Positive | 58 | 64.4 | 50 | 36 |  |
 mTOR (N = 229) | |||||
  Negative | 36 | 40 | 48 | 34.5 | 0.40 |
  Positive | 54 | 60 | 91 | 65.5 |  |
 PTEN (N = 183) | |||||
  Negative (0–1) | 47 | 65.3 | 55 | 49.5 | 0.036 |
  Positive (2–3) | 25 | 34.7 | 56 | 50.5 |  |
 c-MYC (N = 188) | |||||
  Both negative | 19 | 24.4 | 41 | 37.3 | 0.011 |
  Both positive | 27 | 34.6 | 31 | 28.2 |  |
  Cytoplasmic only | 28 | 35.9 | 22 | 20 |  |
  Nuclear only | 4 | 5.1 | 16 | 14.5 |  |
Mutations | |||||
 PIK3CA (N = 176) | |||||
  WT | 49 | 69 | 88 | 83.3 | 0.020 |
  Mutant | 22 | 31 | 17 | 16.2 |  |
Gene CN by qPCR | |||||
 MET (N = 159) | |||||
  No gain | 42 | 71.2 | 77 | 77 | 0.41 |
  Gain | 17 | 28.8 | 23 | 23 |  |
 MYC (N = 159) | |||||
  No gain | 54 | 90 | 90 | 90.9 | 0.85 |
  Gain | 6 | 10 | 9 | 9.1 |  |
Gene status by FISH | |||||
 MET (N = 164) | |||||
  Non-amplified | 56 | 100 | 104 | 96.3 | 0.15 |
  Amplified |  |  | 4 | 3.7 |  |
 MYC (N = 173) | |||||
  Non-amplified | 56 | 88.9 | 86 | 78.2 | 0.077 |
  Amplified | 7 | 11.1 | 24 | 21.8 |  |
 TOP2A (N = 226) | |||||
  Non-amplified | 82 | 93.2 | 74 | 53.6 | <0.001 |
  Amplified | 6 | 6.8 | 64 | 46.4 |  |
 CEN17 (N = 226) | |||||
  Normal | 82 | 93.2 | 119 | 86.2 | 0.10 |
  Increased | 6 | 6.8 | 19 | 13.8 |  |
 CEN7 (N = 170) | |||||
  Normal | 54 | 90 | 101 | 91.8 | 0.69 |
  Increased | 6 | 10 | 9 | 8.2 |  |
 CEN8 (N = 174) | |||||
  Normal | 47 | 74.6 | 79 | 71.2 | 0.63 |
  Increased | 16 | 25.4 | 32 | 28.8 |  |
 CEN profiles (N = 170) | |||||
  0 chromosomes | 40 | 66.7 | 60 | 54.5 | 0.21 |
  1 chromosome | 13 | 21.7 | 41 | 37.3 |  |
  2 chromosomes | 6 | 10 | 8 | 7.3 |  |
  3 chromosomes | 1 | 1.7 | 1 | 0.9 |  |
mRNA | |||||
 MET (N = 139) | |||||
  Low | 36 | 63.2 | 36 | 43.9 | 0.025 |
  High (≥50th perc.) | 21 | 36.8 | 46 | 56.1 |  |
 MYC (N = 140) | |||||
  Low | 36 | 63.2 | 37 | 44.6 | 0.031 |
  High (≥50th perc.) | 21 | 36.8 | 46 | 55.4 |  |