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Table 2 Marker associations according to central HER2 status

From: MYC copy gain, chromosomal instability and PI3K activation as potential markers of unfavourable outcome in trastuzumab-treated patients with metastatic breast cancer

  HER2-negative HER2-positive p value
Ki67 (%)
 Median (range) 38 (1–90) 40 (1–90) 0.12
HER2 copies (FISH)
 Median (range) 2 (1–9) 13 (2–39) <0.001
 Mean (±SD) 3 (1) 14 (8)  
HER2 ratio (FISH)
 Median (range) 1 (1–8) 5 (1–28) <0.001
 Mean (±SD) 1 (1) 7 (4)  
CEN17
 Median (range) 2 (1–4) 2 (1–4) 0.006
 Mean (±SD) 2 (1) 2 (1)  
CEN8
 Median (range) 3 (1–9) 2 (1–5) 0.80
 Mean (±SD) 3 (1) 3 (1)  
CEN7
 Median (range) 2 (1–4) 2 (1–5) 0.50
 Mean (±SD) 2 (1) 2 (1)  
  1. Significant p values are shown in italics
  N % N % p value
IHC, categorical
 ER (N = 229)
  Negative 16 17.8 60 43.2 <0.001
  Positive 74 82.2 79 56.8  
 PgR (N = 229)
  Negative 32 35.6 89 64 <0.001
  Positive 58 64.4 50 36  
 mTOR (N = 229)
  Negative 36 40 48 34.5 0.40
  Positive 54 60 91 65.5  
 PTEN (N = 183)
  Negative (0–1) 47 65.3 55 49.5 0.036
  Positive (2–3) 25 34.7 56 50.5  
 c-MYC (N = 188)
  Both negative 19 24.4 41 37.3 0.011
  Both positive 27 34.6 31 28.2  
  Cytoplasmic only 28 35.9 22 20  
  Nuclear only 4 5.1 16 14.5  
Mutations
 PIK3CA (N = 176)
  WT 49 69 88 83.3 0.020
  Mutant 22 31 17 16.2  
Gene CN by qPCR
 MET (N = 159)
  No gain 42 71.2 77 77 0.41
  Gain 17 28.8 23 23  
 MYC (N = 159)
  No gain 54 90 90 90.9 0.85
  Gain 6 10 9 9.1  
Gene status by FISH
 MET (N = 164)
  Non-amplified 56 100 104 96.3 0.15
  Amplified    4 3.7  
 MYC (N = 173)
  Non-amplified 56 88.9 86 78.2 0.077
  Amplified 7 11.1 24 21.8  
 TOP2A (N = 226)
  Non-amplified 82 93.2 74 53.6 <0.001
  Amplified 6 6.8 64 46.4  
 CEN17 (N = 226)
  Normal 82 93.2 119 86.2 0.10
  Increased 6 6.8 19 13.8  
 CEN7 (N = 170)
  Normal 54 90 101 91.8 0.69
  Increased 6 10 9 8.2  
 CEN8 (N = 174)
  Normal 47 74.6 79 71.2 0.63
  Increased 16 25.4 32 28.8  
 CEN profiles (N = 170)
  0 chromosomes 40 66.7 60 54.5 0.21
  1 chromosome 13 21.7 41 37.3  
  2 chromosomes 6 10 8 7.3  
  3 chromosomes 1 1.7 1 0.9  
mRNA
 MET (N = 139)
  Low 36 63.2 36 43.9 0.025
  High (≥50th perc.) 21 36.8 46 56.1  
 MYC (N = 140)
  Low 36 63.2 37 44.6 0.031
  High (≥50th perc.) 21 36.8 46 55.4  
  1. Significant p values are shown in italics