Skip to main content

Table 3 Cox regression analysis of relative risks of death within 5 years according to EGFR and PODXL expression in colorectal cancer

From: Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer

 

Cohort 1

Cohort 2

Cohort 3

HR (95 % CI)

HR (95 % CI)

N (events)

HR (95 % CI)

HR (95 % CI)

N (events)

HR (95 % CI)

HR (95 % CI)

N (events)

Unadjusted

Adjusted

Unadjusted

Adjusted

Unadjusted

Adjusted

All

 EGFR low

1.00

1.00

419 (146)

1.00

1.00

202 (101)

1.00

1.00

259 (88)

 EGFR high

1.82 (1.35–2.46)

1.77 (1.27–2.46)

114 (61)

1.98 (1.39–2.84)

1.58 (1.05–2.38)

57 (43)

2.60 (1.74–3.89)

1.83 (1.19–2.81)

51 (33)

All

 PODXL low

1.00

1.00

464 (168)

1.00

1.00

235 (123)

1.00

1.00

291 (103)

 PODXL high

1.73 (1.21–2.46)

1.16 (0.77–1.73)

72 (38)

2.27 (1.43–3.62)

1.91 (1.11–3.27)

25 (21)

3.45 (2.13–5.58)

1.23 (0.68–2.22)

25 (20)

EGFR low

 PODXL low

1.00

1.00

373 (128)

1.00

1.00

183 (89)

1.00

1.00

247 (82)

 PODXL high

1.06 (0.58–1.91)

0.87 (0.45–1.66)

34 (12)

2.02 (1.02–4.02)

2.59 (1.26–5.31)

12 (9)

1.62 (0.65–3.99)

0.74 (0.28–1.95)

10 (5)

EGFR high

 PODXL low

1.00

1.00

75 (35)

1.00

1.00

44 (31)

1.00

1.00

37 (19)

 PODXL high

1.97 (1.18–3.28)

1.38 (0.71–2.68)

37 (26)

1.60 (0.80–3.21)

1.69 (0.74–3.84)

12 (11)

3.56 (1.75–7.22)

3.71 (1.23–11.20)

14 (14)

  1. Cohort 1 and 2 adjusted for age at surgery, sex, PODXL, EGFR, T-, N-, M-stage, differentiation grade and vascular invasion in multivariable analysis
  2. Cohort 3 adjusted for age at surgery, sex, PODXL, EGFR, T-, N-, M-stage, differentiation grade, vascular invasion and neural invasion in multivariable analysis