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Table 3 Cox regression analysis of relative risks of death within 5 years according to EGFR and PODXL expression in colorectal cancer

From: Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer

  Cohort 1 Cohort 2 Cohort 3
HR (95 % CI) HR (95 % CI) N (events) HR (95 % CI) HR (95 % CI) N (events) HR (95 % CI) HR (95 % CI) N (events)
Unadjusted Adjusted Unadjusted Adjusted Unadjusted Adjusted
All
 EGFR low 1.00 1.00 419 (146) 1.00 1.00 202 (101) 1.00 1.00 259 (88)
 EGFR high 1.82 (1.35–2.46) 1.77 (1.27–2.46) 114 (61) 1.98 (1.39–2.84) 1.58 (1.05–2.38) 57 (43) 2.60 (1.74–3.89) 1.83 (1.19–2.81) 51 (33)
All
 PODXL low 1.00 1.00 464 (168) 1.00 1.00 235 (123) 1.00 1.00 291 (103)
 PODXL high 1.73 (1.21–2.46) 1.16 (0.77–1.73) 72 (38) 2.27 (1.43–3.62) 1.91 (1.11–3.27) 25 (21) 3.45 (2.13–5.58) 1.23 (0.68–2.22) 25 (20)
EGFR low
 PODXL low 1.00 1.00 373 (128) 1.00 1.00 183 (89) 1.00 1.00 247 (82)
 PODXL high 1.06 (0.58–1.91) 0.87 (0.45–1.66) 34 (12) 2.02 (1.02–4.02) 2.59 (1.26–5.31) 12 (9) 1.62 (0.65–3.99) 0.74 (0.28–1.95) 10 (5)
EGFR high
 PODXL low 1.00 1.00 75 (35) 1.00 1.00 44 (31) 1.00 1.00 37 (19)
 PODXL high 1.97 (1.18–3.28) 1.38 (0.71–2.68) 37 (26) 1.60 (0.80–3.21) 1.69 (0.74–3.84) 12 (11) 3.56 (1.75–7.22) 3.71 (1.23–11.20) 14 (14)
  1. Cohort 1 and 2 adjusted for age at surgery, sex, PODXL, EGFR, T-, N-, M-stage, differentiation grade and vascular invasion in multivariable analysis
  2. Cohort 3 adjusted for age at surgery, sex, PODXL, EGFR, T-, N-, M-stage, differentiation grade, vascular invasion and neural invasion in multivariable analysis